PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing
نویسندگان
چکیده
منابع مشابه
Chitosan Scaffold for Wound Healing Application
-Chitosan is natural polysaccharide resembles with glycosaminoglycan of Extra Cellular matrix (ECM), which makes it a promising candidate for wound healing application apart from its excellent biocompatibility and biodegradability. In this study we have formulated various types of chitosan gel by dissolving different concentrations of chitosan powder in 100 ml of 2% acetic acid separately. Elec...
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The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote ang...
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PURPOSE To investigate the effects of a single prolonged exposure to recombinant epidermal growth factor on the healing of anterior keratotomy wounds in New Zealand white rabbits. METHODS After wounding, eyes were perfused for 1, 2, 4, and 8 hours with either epidermal growth factor solution at a concentration of 50 micrograms/ml or balanced saline solution using a Morgan therapeutic lens (Mo...
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Chitosan-poly(ethylene glycol)-tyramine (CPT) hydrogels were rapidly formed in situ using horseradish peroxidase and hydrogen peroxide to explore their performance as efficient tissue adhesives. A poly(ethylene glycol) modified with tyramine was grafted onto a chitosan backbone to enhance the solubility of the chitosan and to crosslink into three-dimensional networks. The elastic modulus of the...
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OBJECTIVE To develop a chitosan-based scaffold and carry out a complete comprehensive study encompassing optimization of exact chitosan strength, product characterization, toxicity evaluation, in vitro validation in cell culture experiments, and finally in vivo efficacy in animal excision wound model. MATERIALS AND METHODS Developed chitosan scaffolds (CSs) were optimized for tissue engineeri...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-55214-7